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Interactive video lesson plan for: Acetoacetic Ester Synthesis Reaction Mechanism - Substituted Ketones

Activity overview:

This video discusses the acetoacetic ester synthesis reaction mechanism to produced substituted ketone derivatives. This reaction begins with the removal of an alpha hydrogen by sodium ethoxide to produce a resonance stabilized carbanion intermediate. The second step is an SN2 reaction with an alkyl halide to add an R group followed by acid hydrolysis to convert the esters to a carboxylic acid. The last step involves decarboxylation or removal of the carboxylic acid functional group in the form of CO2.

Tagged under: acetoacetic ester synthesis,acetoacetic ester synthesis mechanism,decarboxylation,sn2 reaction,alkyl halide,sodium ethoxide,substituted ketone derivatives

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