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Interactive video lesson plan for: 37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products

Activity overview:

Freshman Organic Chemistry II (CHEM 125B)

Modern spectroscopic tools show not only the constitution, configuration, and conformation of glucose but also how it interconverts between isomeric hemiketal pyranose rings. One of mankind's great accomplishments was determinining its constitution and especially its configuration before such spectroscopy. By 1887 Heinrich Kiliani had established the constitution of glucose as an aldohexose, and with help from Emil Fischer, he developed a method for homologating aldoses. Fisher assembled a great deal of experimental evidence on interconversion of natural and artificial aldoses, and their derivatives, especially their crystalline osazones. In 1892 he used this evidence to prove logically which of eight aldohexose configurations corresponds to glucose and to provide definitive support for van't Hoff's stereochemical theory. In 1991 Cram, Tanner, and Thomas reported the NMR spectrum of antiaromatic cyclobutadiene, which they prepared by photolysis inside a clamshell molecule that they designed and constructed in order to isolate this highly reactive molecule.

00:00 - Chapter 1. Glucose Structure by IR, NMR, and X-Ray
08:12 - Chapter 2. Glucose Constitution from van't Hoff to the Kiliani-Fischer Synthesis
23:28 - Chapter 3. Fischer's Osazones, Fischer's Projection, and Fischer's Evidence
35:25 - Chapter 4. Fischer's Proof of the Configuration of Glucose
47:16 - Chapter 5. Synthesizing a Cyclobutadiene Precursor in a Designer Clamshell
52:52 - Chapter 6. The Antiaromaticity of Cyclobutadiene

Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu

This course was recorded in Spring 2011.

Tagged under: glucose,hemiketal,rotation,Kiliani-Fischer synthesis,phenylhydrazine,osazone,D-aldohexose,pentose,tetrose,glucaric acid,mannitol,gulose,arabinose,xylose,2-pyranone,cyclobutadiene,clamshell cage,antiaromatic

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